%0 Journal Article
%T Low prevalence of antiŠ\xenobiotic antibodies among the occupationally exposed individuals is associated with a high risk of cancer
%A Javed N. Agrewala
%A Mohammad Sajid
%J Archive of "Cancer Medicine".
%D 2019
%R 10.1002/cam4.1773
%X Cancer is one of the major health problem globally, responsible for high morbidity and mortality. Exposure of humans to xenobiotics is associated with the development of cancer. Further, these xenobiotics may combine with the body proteins and can act as a hapten and elicit an antibody response. In this study, we examined whether the regular exposer to xenobiotics evokes antiŠ\xenobiotic antibodies and the presence of these antibodies have any correlation with the prevention of cancer. Interestingly, we noticed that the healthy household contacts showed significantly greater titers of antiŠ\xenobiotic antibodies, as compared to cancer patients. Consequently, suggesting that the higher level of antiŠ\xenobiotic antibodies may be responsible for neutralizing the effect of xenobiotics in the healthy subjects. Thereby, preventing the individuals from disease. In contrast, the presence of a significantly lower level of antiŠ\xenobiotic antibodies in the cancer patients may be a causative factor for disease infliction. In conclusion, immunotherapy employing antiŠ\xenobiotic antibodies may provide a prudent remedial measure to clear xenobiotics from the body of the individuals and thereby protecting from cancer
%K antiŠ\xenobiotic antibodies
%K breast cancer
%K cancer
%K household contacts
%K pesticides
%K xenobiotics
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346253/