%0 Journal Article
%T Genetic polymorphism of rs9564966 G£¿>£¿A on 13q22.1 predicts poor survival for Chinese patients with gastric cancer
%A Jinfei Chen
%A Tingting Zhao
%A Xinying Huo
%J Archive of "Cancer Medicine".
%D 2019
%R 10.1002/cam4.1693
%X Two genomewide association studies on pancreatic cancer have identified a novel single©\nucleotide polymorphism of rs9564966 G > A on 13q22.1 region. However, the associations between the rs9564966 G > A polymorphism and the survival of Chinese patients with gastric cancer (GC) were unknown. In our present investigation, we adopted the Kaplan©\Meier plots, Cox regression analyses, and the log©\rank tests to explore the associations between rs9564966 G > A polymorphism and the prognosis of 911 Chinese patients with GC. Our results revealed that, compared with GG genotype, patients with GA + AA genotypes had poorer outcomes (HR = 1.348, 95% CI = 1.084©\1.675, P = 0.007), especially in the subgroups of age ¡Ü60 years, male, nondrinker, tumor size >5 cm, tumor site in Noncardia, intestinal©\type tumor, T3/T4 level depth of invasion, N1/N2/N3 level lymph node metastasis, no distant metastasis, III/IV level TNM stages, and no chemotherapy. Our findings suggested that the rs9564966 G > A polymorphism may be a potential biomarker to predict the survival of Chinese patients with GC
%K 13q22.1
%K gastric cancer
%K rs9564966
%K single©\nucleotide polymorphism
%K survival
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346249/