%0 Journal Article
%T An Introduction to the Mathematical Modeling in the Study of Cancer
Systems Biology
%A Abdallah K Alameddine
%A Brian Binnall
%A Frederick Conlin
%J Archive of "Cancer Informatics".
%D 2018
%R 10.1177/1176935118799754
%X Frequently occurring in cancer are the aberrant alterations of regulatory onco-metabolites, various oncogenes/epigenetic stochasticity, and suppressor genes, as well as the deficient mismatch repair mechanism, chronic inflammation, or those deviations belonging to the other cancer characteristics. How these aberrations that evolve overtime determine the global phenotype of malignant tumors remains to be completely understood. Dynamic analysis may have potential to reveal the mechanism of carcinogenesis and can offer new therapeutic intervention
%K cancer biology
%K mathematical modeling
%K time series snapshots
%K biomarkers
%K systems biology
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136108/