%0 Journal Article
%T The prognostic value of immunoscore in patients with colorectal cancer: A systematic review and meta©\analysis
%A Ensheng Zhao
%A Guorui Sun
%A Hao Zhang
%A Hui Qu
%A Xiaolong Tang
%A Xiaoyuan Dong
%J Archive of "Cancer Medicine".
%D 2019
%R 10.1002/cam4.1921
%X The tumor immune infiltrate, as recently evaluated with the immunoscore methodology, has been reported to be related to colorectal cancer (CRC) progression. Nevertheless, results varied from different studies. A meta©\analysis was conducted to solve this problem. We collected data from included studies to evaluate the prognostic role of immunoscore in CRC patients on overall survival (OS) and disease©\free survival (DFS). MEDLINE, EMBASE, and Cochrane libraries were searched through 30 June 2018. Hazard ratio (HR) with 95% confidence intervals (95% CI) was pooled using a random©\effects model for OS and a fixed©\effects model for DFS. Finally, eight studies (involving 4689 CRC cases) were identified as eligible publications. The results of the meta©\analysis showed that low immunoscore was significantly correlated with poor OS (HR = 1.74, 95% CI: 1.43©\2.13) and DFS (HR = 1.82, 95% CI: 1.64©\2.03). The findings from most subgroup analyses were consistent with those from the overall analysis. The immunoscore could be a useful prognostic marker in patients with CRC. It is necessary to evaluate immunological markers in international multicenter studies
%K colorectal cancer
%K immunoscore
%K meta©\analysis
%K prognosis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346241/