%0 Journal Article
%T Nationwide genetic testing towards eliminating Lafora disease from Miniature Wirehaired Dachshunds in the United Kingdom
%A Berge A. Minassian
%A Clare Rusbridge
%A Gill Key
%A Ian Seath
%A Peixiang Wang
%A Saija Ahonen
%A Susan Holt
%A Travis Wang
%J Archive of "Canine Genetics and Epidemiology".
%D 2018
%R 10.1186/s40575-018-0058-8
%X Genotyping is performed using Southern blot. Southern blot is used for genotyping as PCR based methods cannot reliably distinguish the different genotypes due to the type of the mutation. The affected dogs (A) are homozygous for the dodecamer repeat expansion mutation with multiple dodecamer repeats, carrier (C) dogs have the normal and mutated allele and clear dogs (WT) have three copies of the repeat [8
%K Canine polyglucosan storage disease
%K Progressive myoclonic epilepsy
%K Miniature Wirehaired Dachshund
%K DNA testing
%K Genetic diversity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869781/