%0 Journal Article
%T Evaluation of a Simple and Safe Tumor Drilling Technique to
Potentiate the Effect of Intraperitoneal Chemotherapy in the Treatment of
Recurrent Epithelial Ovarian, Tubal, and Peritoneal Cancer: A Matched
Retrospective Cohort Study
%A Chi-Mu Chuang
%A Ching-Hui Chien
%A Chung-Ru Lai
%A Hui-Ju Wu
%A Wei-Ting Chao
%J Archive of "Cancer Control : Journal of the Moffitt Cancer Center".
%D 2019
%R 10.1177/1073274819863778
%X Frontline intraperitoneal chemotherapy (IPCT) in the treatment of epithelial ovarian cancer has been well established. However, the role of second-line IPCT is yet to be confirmed. With a view to implementing IPCT to treat recurrent disease, a prerequisite is to perform a cytoreductive procedure to minimize residual tumor size. However, the role of cytoreductive procedure is still in debate due to a higher chance of complications. A matched retrospective cohort study was conducted. From 2008 to 2015, we adopted a relatively simple and safe tumor drilling technique to maximize tumor exposure to second-line IPCT. Patients who received tumor drilling followed by second-line IPCT constituted the cohort group. Concurrently, patients who received standard second-line systemic chemotherapy were selected as the comparison group. After propensity score matching, 85 patients in each group entered into the final analysis. The median progression-free survival was 7.3 months (95% confidence interval [CI], 6.2-7.8) for the cohort group versus 4.1 months (95% CI, 4.0-4.3) for the comparison group (hazard ratio = 0.25 [95% CI, 0.17-0.36]; P < .001, by log-rank test). The median overall survival was 33.6 months (32.1-36.6) for the cohort group versus 25.9 months (20.5-26.9) for the comparison group (hazard ratio = 0.33 [95% CI, 0.23-0.48]; P < .001, by log-rank test). Toxicities in the cohort group were not different from those that were published in reports of IPCT for ovarian cancer. The most commonly observed toxicity was gastrointestinal origin (51.7%), and it may be attributed to the intraperitoneal pharmacokinetic clearance of cisplatin and taxol and we also discussed the mechanism of gastrointestinal toxicity. Tumor drilling followed by second-line IPCT may confer a survival advantage over standard second-line systemic chemotherapy in the treatment of recurrent ovarian cancer
%K intraperitoneal chemotherapy
%K recurrent ovarian cancer
%K tumor drilling
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6659185/