%0 Journal Article
%T A Holistic Approach to Risk for Early Kidney Injury in Indigenous
Youth With Type 2 Diabetes: A Proof of Concept Paper From the iCARE
Cohort
%A Allison B. Dart
%A Atul Sharma
%A Brandy Wicklow
%A Dan Chateau
%A Elizabeth A. C. Sellers
%A Jonathan M. McGavock
%A Sayma Malik
%A Tom D. Blydt-Hansen
%J Archive of "Canadian Journal of Kidney Health and Disease".
%D 2019
%R 10.1177/2054358119838836
%X Indigenous youth with type 2 diabetes (T2D) are disproportionately affected by early onset albuminuria and are at high risk of kidney failure in early adulthood. Traditional biological approaches have failed to fully explain the renal morbidity seen in this population. The improving renal Complications in Adolescents with type 2 diabetes through REsearch cohort (iCARE) study was therefore designed in collaboration with patients, to more holistically evaluate risk factors for renal morbidity. We hypothesize that both biological factors and mental health influence renal outcomes, mediated via inflammatory pathways
%K type 2 diabetes
%K youth
%K albuminuria
%K structural equation model
%K holistic
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477761/