%0 Journal Article
%T Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)
%A Hyunseok Kang
%A Kyungsuk Jung
%A Ranee Mehra
%J Archive of "Cancers of the Head & Neck".
%D 2018
%R 10.1186/s41199-018-0030-z
%X Linear composition of p110¦Á and p85¦Á molecules. Red arrowheads in p110¦Á indicate ¡®hotspot¡¯ mutations. C2 in p110¦Á is a putative membrane-binding domain. Breakpoint cluster region-homology (BH) domain in p85¦Á has shown GTPase activating protein (GAP) activity toward Rab family. Rab GTPase induces degradation and deregulation of activated growth factor receptors, and mutated Rab GAP induces cell transformation [148]. However, it is unclear if this function is still active in complex with p110¦Á [149]. BH domain in p85¦Á is flanked by proline-rich domain, implying an auto-regulatory mechanism in interaction with its SH3 domain [150
%K HNSCC
%K PI3K
%K mTOR
%K Akt
%K EGFR
%K PIK3CA
%K HPV
%K Drug resistance
%K Precision medicine
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460806/