%0 Journal Article
%T The impact of incorrectly recorded parentage on inferred genotypes over multiple generations
%A T. W. Lewis
%J Archive of "Canine Genetics and Epidemiology".
%D 2019
%R 10.1186/s40575-019-0074-3
%X Diagrammatic representation of the iterative calculation of genotype probabilities of progeny over successive generations of individuals assigned ¡®hereditary clear¡¯ (HC) status. The actual sire genotype probabilities are the genotype frequencies in the background population assumed in HWE, occurring at a constant false paternity rate of 5%. The initial dam and nominated sire genotype probabilities are from individuals with genotypes known from testing, so P (AA)£¿=£¿1. Thereafter over successive generations, the calculated genotype probabilities of progeny (assigned HC status) in generation n become the parent genotype probabilities in generation n£¿+£¿
%K Disease mutations
%K Genetic testing
%K Disease carriers
%K Hereditary clear status
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639963/