%0 Journal Article
%T A genetic assessment of the English bulldog
%A Ashley S. Pooch
%A Hongwei Liu
%A Niels C. Pedersen
%J Archive of "Canine Genetics and Epidemiology".
%D 2016
%R 10.1186/s40575-016-0036-y
%X This study examines genetic diversity among 102 registered English Bulldogs used for breeding based on maternal and paternal haplotypes, allele frequencies in 33 highly polymorphic short tandem repeat (STR) loci on 25 chromosomes, STR-linked dog leukocyte antigen (DLA) class I and II haplotypes, and the number and size of genome-wide runs of homozygosity (ROH) determined from high density SNP arrays. The objective was to assess whether the breed retains enough genetic diversity to correct the genotypic and phenotypic abnormalities associated with poor health, to allow for the elimination of deleterious recessive mutations, or to make further phenotypic changes in body structure or coat. An additional 37 English bulldogs presented to the UC Davis Veterinary Clinical Services for health problems were also genetically compared with the 102 registered dogs based on the perception that sickly English bulldogs are products of commercial breeders or puppy-mills and genetically different and inferior
%K English bulldog
%K Health
%K Genetic assessment
%K Short tandem repeats (STRs)
%K Maternal haplotypes
%K Paternal haplotypes
%K Internal relatedness (IR)
%K Dog leukocyte antigen (DLA)
%K DLA class I and II
%K Runs of homozygosity (ROH)
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965900/