%0 Journal Article
%T Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
%A Baoyu Zhao
%A Jin Jin
%A Lele Zhu
%A Pingwei Li
%A Shao-Cong Sun
%A Xiaoping Xie
%A Xuhong Cheng
%A Yanchuan Li
%A Zuliang Jie
%J Archive of "Cell & Bioscience".
%D 2019
%R 10.1186/s13578-018-0268-5
%X Survival of Traf3 conditional KO mice following VSV infection. a Age-matched (6¨C8 weeks old) WT and Traf3MKO mice were infected i.v. with VSV (1£¿¡Á£¿107 PFU per mouse). Data are presented as 8 animals/group. b Traf3DC-KO and WT littermate control mice were infected i.v. with VSV (2£¿¡Á£¿107 PFU per mouse). Survival was recorded and presented as 8 mice per group. c Immunoblot analysis of the indicated proteins in the extracts of splenocytes or LN cells derived from Tamoxifen-treated WT and TRAF3IKO mice. d WT and TRAF3IKO mice (n£¿=£¿15) were infected with VSV (2£¿¡Á£¿107 PFU per mouse) via tail vein. Data representative of two independent experiments, and statistical significance was determined by log-rank and Gehan-Wilcoxon tests. p£¿<£¿0.05 indicates significantly differen
%K TRAF2
%K TRAF3
%K Type I interferon
%K Antiviral immunity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318904/