%0 Journal Article
%T IL-33 ameliorates experimental colitis involving regulation of autophagy of macrophages in mice
%A Chang Qi
%A Lifeng Shi
%A Min Fang
%A Shuyao Hua
%A Zhongyan Wang
%J Archive of "Cell & Bioscience".
%D 2019
%R 10.1186/s13578-019-0271-5
%X Treatment with 2,4,6-trinitrobenzenesulfonic acid (TNBS) enhanced the autophagy in mice with colitis. BALB/c mice were given 2.5 mg/mouse TNBS (dissolved in 50% ethanol) or the vehicle ethanol intrarectally. All the mice were sacrificed on fourth day. a Body weight changes were monitored between zeroth to fourth day in different groups of mice. b Colon lengths were measured. c Histological analysis (hematoxylin and eosin staining) of mice colons was determined under microscope (original magnification,£¿¡Á200). d Extracts from colons were subjected to LC3 western blotting to evaluate for treatment with TNBS versus the vehicle ethanol. Values were mean£¿¡À£¿SD. The asterisk indicates p£¿<£¿0.05. Data were presented as means£¿+£¿SD of three to six individual mice per group and represent£¿>£¿three independent experimental repeat
%K IL-33
%K TNBS-induced experimental colitis
%K Autophagy
%K Macrophages
%K TLR4
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332617/