%0 Journal Article
%T Genetic mapping of principal components of canine pelvic morphology
%A Adam R. Boyko
%A Jessica J. Hayward
%A Joy Li
%A Kei Hayashi
%A Marina J. McConkey
%A Mark J. Fealey
%A Rebel J. E. Todhunter
%A Rory J. Todhunter
%A Ursula Krotscheck
%J Archive of "Canine Genetics and Epidemiology".
%D 2017
%R 10.1186/s40575-017-0043-7
%X Concentrated breeding effort to produce various body structures and behaviors of dogs to suit human demand has inadvertently produced unwanted traits and diseases that accompany the morphological and behavioral phenotypes. We explored the relationship between pelvic conformation and canine hip dysplasia (HD) because purebred dogs which are predisposed, or not, to HD share common morphologic features, respectively. Thirteen unique bilateral anatomical features of the pelvis were measured on 392 dogs of 51 breeds and 95 mixed breed dogs. Principal components (PCs) were derived to describe pelvic morphology. Dogs were genotyped at ~183,000 single nucleotide polymorphisms and their hip conformation was measured by the Norberg angle and angle of inclination between the femoral neck and diaphysis
%K Dog
%K GWAS
%K Principal component analysis
%K IGF-1
%K Pelvic sexual dimorphism
%K Norberg angle
%K Hip dysplasia
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364603/