%0 Journal Article
%T KDM4B is a coactivator of c-Jun and involved in gastric carcinogenesis
%A Chih-Pin Chuu
%A Hsin-Hung Cheng
%A Hsing-Jien Kung
%A Meng-Chen Wu
%A Shu Chien
%A Ta-Sen Yeh
%A Tsan-Jan Chen
%A Wei Yang Sit
%A Wen-Ching Wang
%A Yi-Chen Li
%J Archive of "Cell Death & Disease".
%D 2019
%R 10.1038/s41419-019-1305-y
%X a Generation of KDM4A-, KDM4B-, and KDM4C-knockdown AGS cells. Cells were infected with lentivirus using a control shRNA (pLKO) and two independent short-hairpin constructs to generate shKDM4A (sh4A#1 and sh4A#2), shKDM4B (sh4B#1 and sh4B#2), and shKDM4C (sh4C#1 and sh4C#2), respectively. Depletion of KDM4A, KDM4B, or KDM4C was confirmed by western blotting analysis. ¦Â-Actin was the internal control. b IL-8 release was measured from the supernatants of non-infected or H. pylori-infected cells by ELISA. Data represent the mean£¿¡À£¿standard deviation (SD) from three independent experiments. c Images of cytokine arrays for the detection of the relative levels of cytokines from supernatants of pLKO and sh4B#1 cells, respectively. Cells were non-infected (£¿Hp) or infected with H. pylori (+£¿Hp) at an moi of 50 for 6£¿h. d The relative fold of IL-8, CXCL1, and CCL5 was measured and shown as a ratio of pLKO (£¿Hp) levels from (c). *p£¿<£¿0.05; **p£¿<£¿0.0
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347645/