%0 Journal Article
%T OMICs approaches-assisted identification of macrophages-derived MIP-1¦Ã as the therapeutic target of botanical products TNTL in diabetic retinopathy
%A Cheng Zhang
%A Hor-Yue Tan
%A Ning Wang
%A Sha Li
%A Wen Xia
%A Yibin Feng
%A Yu Xu
%J Archive of "Cell Communication and Signaling : CCS".
%D 2019
%R 10.1186/s12964-019-0396-5
%X High doses of TNTL possessed hypoglycemic effects. a. showed that TNTL treatment did not significantly change the body weight of hyperglycemic mice; b. showed that TNTL dose-dependently suppressed the increase of random blood glucose (RBG) by week; c. showed that TNTL dose-dependently reduced fasting blood glucose (FBG) after 4-week treatment; d. showed that medium and high doses of TNTL improved the glucose tolerance in hyperglycemic mice; e. showed that TNTL at medium and high doses can significantly reduce serum HbA1c levels. *p£¿<£¿0.05, **p£¿<£¿0.01, ***p£¿<£¿0.001 when compared with model grou
%K Tang-Ning-Tong-Luo
%K Diabetic retinopathy
%K Inflammation
%K Endothelial dysfunctions
%K MIP1¦Ã/CCR1 axis
%K Retina macrophages
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6647109/