%0 Journal Article
%T Transcriptomics Signature from Next-Generation Sequencing Data
Reveals New Transcriptomic Biomarkers Related to Prostate Cancer
%A Abedalrhman Alkhateeb
%A Dora Cavallo-Medved
%A Iman Rezaeian
%A Lisa A Porter
%A Luis Rueda
%A Siva Singireddy
%J Archive of "Cancer Informatics".
%D 2019
%R 10.1177/1176935119835522
%X Prostate cancer is one of the most common types of cancer among Canadian men. Next-generation sequencing using RNA-Seq provides large amounts of data that may reveal novel and informative biomarkers. We introduce a method that uses machine learning techniques to identify transcripts that correlate with prostate cancer development and progression. We have isolated transcripts that have the potential to serve as prognostic indicators and may have tremendous value in guiding treatment decisions. Analysis of normal versus malignant prostate cancer data sets indicates differential expression of the genes HEATR5B, DDC, and GABPB1-AS1 as potential prostate cancer biomarkers. Our study also supports PTGFR, NREP, SCARNA22, DOCK9, FLVCR2, IK2F3, USP13, and CLASP1 as potential biomarkers to predict prostate cancer progression, especially between stage II and subsequent stages of the disease
%K prostate cancer progression
%K transcriptomics signature
%K machine learning
%K RNA-Seq analysis
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416685/