%0 Journal Article
%T Bile Cast Nephropathy: A Pathologic Finding with Manifold Causes Displayed in an Adult with Alcoholic Steatohepatitis and in a Child with Wilson's Disease
%A Allen R. Hendricks
%A Daniel Burguete
%A Jose Torrealba
%A Nathan T. Sweed
%J Archive of "Case Reports in Nephrology and Dialysis".
%D 2018
%R 10.1159/000493231
%X Bile cast nephropathy (BCN) is seen in patients who have acute kidney injury and severe hyperbilirubinemia due to a wide range of hepatobiliary system diseases. Findings seen by renal biopsy include acute tubular injury with necrotic and sloughed epithelial cells, yellow-green pigment within tubular epithelial cells, and pigmented granular casts. Hall's special stain for bile turns these casts green. In recent years, BCN has been described in a small number of case reports and clinical studies primarily in the setting of severe liver dysfunction. We present 2 diverse cases of BCN. The first involves an adult with hepatorenal syndrome secondary to alcoholic steatohepatitis and early cirrhosis. Second, we describe the first reported case of BCN in a child with fulminant hepatic failure due to Wilson's disease. Our cases expand the spectrum of causative diseases, and they provide further evidence that BCN is a distinct pathologic entity which may be found in both adult and pediatric patients with a variety of severe liver diseases
%K Bile cast nephropathy
%K Cholestatic liver disease
%K Wilson's disease
%K Hepatorenal syndrome
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206956/