%0 Journal Article
%T Therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target
%A Ming Zeng
%A Qing Zhang
%A Sisi Wang
%A Tang Liu
%A Wanchun Wang
%A Zhengxiao Ouyang
%A Zhihong Li
%J Archive of "Cell Communication and Signaling : CCS".
%D 2019
%R 10.1186/s12964-019-0327-5
%X CDK4 expression levels are associated with the clinicopathological characteristics of chondrosarcoma patients. (a) Distribution of CDK4 staining scores in the chondrosarcoma tissue samples from surviving and non-surviving patients. (b) Kaplan-Meier survival curve of sarcoma patients with high staining (¡Ý 3) or low staining (<£¿3) for CDK4. Distribution of CDK4 staining scores in the chondrosarcoma tissue samples from patients with and without metastasis (c), patients with and without recurrence (d). ** means P£¿<£¿0.01 compared with the former group. (e) Representative images of different immunohistochemical staining intensities of CDK4 (Original magnification 200X, scale bar =100£¿¦Ìm). On the basis of the percentage of cells with positive nuclear staining, CDK4 staining patterns were categorized into 6 groups: 0, no nuclear staining; 1+, <£¿10% positive cells; 2+, 10¨C25% positive cells; 3+, 26¨C50% positive cells; 4+, 51¨C75% positive cells; 5+, >£¿75% positive cells. Tumors with a staining score of ¡Ý3 were designated as high CDK4 expression and£¿<£¿3 were designated as low CDK4 expressio
%K Chondrosarocma
%K CDK4
%K Palbociclib
%K Rb
%K Target therapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390580/