%0 Journal Article
%T Fib3-3 as a Biomarker for Osteoarthritis in a Rat Model with Metabolic Dysregulation
%A Christelle Sanchez
%A Floris P. J. G. Lafeber
%A Harrie Weinans
%A Huub M. de Visser
%A Simon C. Mastbergen
%A Yves E. Henrotin
%J Archive of "Cartilage".
%D 2019
%R 10.1177/1947603518754629
%X Fibulin-3 is a glycoprotein highly expressed in osteoarthritic cartilage and inhibits angiogenesis and chondrocyte differentiation. Recent studies have indicated that fibulin-3 has potential value as a biomarker in osteoarthritis. The aim of the present study is to examine the role of 3 fibulin-3 peptides (Fib3-1, Fib3-2, and Fib3-3) and a type II collagen degradation product in a rat osteoarthritis model with systemic metabolic alterations combined with local cartilage damage
%K osteoarthritis
%K biomarker
%K articular cartilage
%K animal model
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585292/