%0 Journal Article %T Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 %A Aaron Ciechanover %A Abhishek D. Garg %A Adi Kimchi %A Alexey V. Antonov %A Ana J. Garc¨ªa-S¨¢ez %A Andreas Linkermann %A Andreas Strasser %A Andreas Villunger %A Andrew Oberst %A Andrew Thorburn %A Antonella Sistigu %A Atan Gross %A Bertrand Joseph %A Beth Levine %A Boris Turk %A Boris Zhivotovsky %A Brent R. Stockwell %A Brian D. Dynlacht %A Carlos L¨®pez-Ot¨ªn %A Carmen Garrido %A Catherine Brenner %A Cecilia M.P. Rodrigues %A Christoph Borner %A Claudio Hetz %A Colin S. Duckett %A Cristina Mu£¿oz-Pinedo %A Daniel J. Klionsky %A Daolin Tang %A David C. Rubinsztein %A David M. Pereira %A David W. Andrews %A David Wallach %A Didac Carmona-Gutierrez %A Dieter Adam %A Domagoj Vucic %A Douglas R. Green %A Edward A. Miao %A Eleonora Candi %A Eli Arama %A Emad S. Alnemri %A Emily H. Cheng %A Emre Sayan %A Enrico Lugli %A Eric H. Baehrecke %A Erwin F. Wagner %A Evripidis Gavathiotis %A Eyal Gottlieb %A Feng Shao %A Francesca Bernassola %A Francesco Cecconi %A Francesco Di Virgilio %A Francis K.-M. Chan %A Frank Madeo %A Gabriel A. Rabinovich %A Gabriel Nu£¿ez %A Gerald M. Cohen %A Gerry Melino %A Gian Maria Fimia %A Guido Kroemer %A Gwenola Manic %A Gyorgy Hajnoczky %A Gyorgy Szabadkai %A Hamsa Puthalakath %A Hans-Uwe Simon %A Henning Walczak %A Herbert W. Virgin %A Hidenori Ichijo %A Hinrich Gronemeyer %A Ilio Vitale %A Isaac S. Harris %A Ivano Amelio %A J. Marie Hardwick %A James A. Wells %A Jan Paul Medema %A Jean-Christophe Marine %A Jean-Claude Martinou %A Jeffery D. Molkentin %A Jerry E. Chipuk %A Jochen H.M. Prehn %A John A. Cidlowski %A John J. Lemasters %A John M. Abrams %A John Silke %A John W. Elrod %A Josef M. Penninger %A Juan R. Cubillos-Ruiz %A Junying Yuan %A Karen H. Vousden %A Katiuscia Bianchi %A Kevin M. Ryan %A Klas Blomgren %J Archive of "Cell Death and Differentiation". %D 2018 %R 10.1038/s41418-017-0012-4 %X Major cell death subroutines. Mammalian cells exposed to unrecoverable perturbations of the intracellular or extracellular microenvironment can activate one of many signal transduction cascades ultimately leading to their demise. Each of such regulated cell death (RCD) modes is initiated and propagated by molecular mechanisms that exhibit a considerable degree of interconnectivity. Moreover, each type of RCD can manifest with an entire spectrum of morphological features ranging from fully necrotic to fully apoptotic, and an immunomodulatory profile ranging from anti-inflammatory and tolerogenic to pro-inflammatory and immunogenic. ADCD: autophagy-dependent cell death, ICD: immunogenic cell death, LDCD: lysosome-dependent cell death, MPT: mitochondrial permeability transition %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239/