%0 Journal Article
%T Giant Congenital Melanocytic Nevi: An Update and Emerging Therapies
%A Girish Gulab Meshram
%A Kanwaljeet Singh Hura
%A Neeraj Kaur
%J Archive of "Case Reports in Dermatology".
%D 2018
%R 10.1159/000487002
%X Giant congenital melanocytic nevi (GCMN) are a rare occurrence. Gain-of-function mutation in the NRAS gene is found to be associated with GCMN, causing abnormal proliferation of embryonic melanoblasts. The two major complications associated with GCMN are malignant melanoma and neurocutaneous melanosis. Treatment of GCMN has conventionally been surgical. However, the role of NRAS inhibitors and inactivation of nevus tissue by high hydrostatic pressure are being explored. We present a case of a 1-day-old neonate born with GCMN, along with a review of the literature
%K Giant congenital melanocytic nevi
%K Neurocutaneous melanosis
%K Malignant melanoma
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836163/