%0 Journal Article
%T Mechanobiology of Cancer Stem Cells and Their Niche
%A Ankit Roy Choudhury
%A Deepak Pandey
%A Neeraj Kumar
%A Pradeep Kumar Chaturvedi
%A Surabhi Gupta
%J Archive of "Cancer Microenvironment".
%D 2019
%R 10.1007/s12307-019-00222-4
%X Schematic representation of the two familiar models of cancer initiation and progression. a. Stochastic model: According to this model, each cancer cell of a tumor is equally potent to continuously divide and form tumor. b. Hierarchical model: According to this model, only few cells called cancer stem cells of a tumor are capable of dividing, differentiating and reinitiating tumor. Other cells are not generally able to perpetuate a tumor, though they possess the ability to dedifferentiate into cancer stem cell
%K Stem cells
%K Niche
%K Stromal remodeling
%K Stiffness
%K Mechanotransduction
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529500/