%0 Journal Article
%T Oxcarbazepine Therapy for Complete Central Diabetes Insipidus
%A Basmah Abdallah
%A Daniel Landry
%A Gregory Braden
%A Michael O'shea
%A Spencer Hodgins
%J Archive of "Case Reports in Nephrology and Dialysis".
%D 2018
%R 10.1159/000485244
%X Oxcarbazepine and carbamazepine cause hyponatremia by unknown mechanisms. We describe a patient with complete central diabetes insipidus and seizures who developed worsening hyponatremia when her dose of oxcarbazepine was increased. The patient maintained a normal serum sodium level and has had appropriately concentrated urine for 5 years on just oxcarbazepine, despite undetectable antidiuretic hormone (ADH) levels. This suggests that oxcarbazepine (or one of its metabolites) may stimulate collecting tubule V2 receptor-G protein complex independent of ADH, resulting in increased renal tubular water reabsorption. Oxcarbazepine may be useful as an alternative therapy for patients with central diabetes insipidus
%K Oxcarbazepine
%K Hyponatremia
%K Diabetes insipidus
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836185/