%0 Journal Article
%T Tolvaptan for Primary Aldosteronism and Autosomal Dominant Polycystic Kidney Disease: A Case Report
%A Akinari Sekine
%A Eiko Hasegawa
%A Hiroki Mizuno
%A Junichi Hoshino
%A Keiichi Sumida
%A Kenmei Takaichi
%A Kyohei Kunizawa
%A Masahiro Kawada
%A Masayuki Yamanouchi
%A Naoki Sawa
%A Noriko Hayami
%A Rikako Hiramatsu
%A Shigeru Shibata
%A Tatsuya Suwabe
%A Yoshifumi Ubara
%J Archive of "Case Reports in Nephrology and Dialysis".
%D 2018
%R 10.1159/000487921
%X A 59-year-old Japanese woman was admitted for evaluation of muscle weakness. Autosomal dominant polycystic kidney disease had been diagnosed at the age of 47 years, followed by primary aldosteronism at 53 years. At the age of 58, tolvaptan was started (60 mg/day) to treat her renal disease. After 8 months of tolvaptan therapy, hypokalemia-related muscle weakness became prominent, and hypertension became refractory. Finally, treatment with low-dose tolvaptan (30 mg/day) and high-dose spironolactone (100 mg/day) normalized serum potassium and the blood pressure. Tolvaptan can induce urinary excretion of potassium in patients with primary aldosteronism, and possible mechanisms are discussed
%K Tolvaptan
%K Autosomal dominant polycystic kidney disease
%K Primary aldosteronism
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5903093/