%0 Journal Article
%T The functional diversity of Aurora kinases: a comprehensive review
%A Arnaud Lombard
%A Bernard Rogister
%A Estelle Willems
%A Marina Digregorio
%A Matthias Dedobbeleer
%A Paul Noel Lumapat
%J Archive of "Cell Division".
%D 2018
%R 10.1186/s13008-018-0040-6
%X Evolution of the Aurora kinase family: Aurora members evolved from a single ancestor gene, called Ipl1 and initially identified in Saccharomyces cerevisiae and other Urochordata (renamed Tunicata). In invertebrates and non-mammalian vertebrates (e.g. Caenorhabditis elegans, Xenopus laevis and Drosophila melanogaster), the Aurora family is constituted by two orthologs: the AURKA (also called AIK1, ARK1, Eg2) and the AURKB (also called AIK2, ARK2, Eg1) ancestor genes. In mammals, AURKB/AURKC ancestor gene duplication gave rise to AURKB and AURKC paralogs. In human, AURKA, AURKB and AURKC map on chromosomes 20q13.2, 17p13.1, and 19q13.43 respectivel
%K Aurora kinase
%K Mitosis
%K Cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146527/