%0 Journal Article
%T The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
%A Haifeng Yang
%A Weijia Cai
%J Archive of "Cell Division".
%D 2016
%R 10.1186/s13008-016-0020-7
%X Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 ubiquitin ligases
%K Cullin-2
%K Elongin
%K E3 ubiquitin ligase
%K VHL
%K Hypoxia inducible factor
%K Rack1
%K E4orf6
%K Viral host defense
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878042/