%0 Journal Article
%T Activation of WEE1 confers resistance to PI3K inhibition in glioblastoma
%A Dimpy Koul
%A Feng Gao
%A Luyuan Li
%A Shaofang Wu
%A Shuzhen Wang
%A Siyuan Zheng
%A W K Alfred Yung
%J Archive of "Neuro-Oncology".
%D 2018
%R 10.1093/neuonc/nox128
%X Oncogenic activation of phosphatidylinositol-3 kinase (PI3K) signaling plays a pivotal role in the development of glioblastoma (GBM). However, pharmacological inhibition of PI3K has so far not been therapeutically successful due to adaptive resistance through a rapid rewiring of cancer cell signaling. Here we identified that WEE1 is activated after transient exposure to PI3K inhibition and confers resistance to PI3K inhibition in GBM
%K mitotic catastrophic cell death
%K PI3K inhibition resistance
%K WEE1
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761544/