%0 Journal Article
%T MerTK as a therapeutic target in glioblastoma
%A Allison N Schorzman
%A C Ryan Miller
%A David M Irvin
%A Erik P Sulman
%A H Shelton Earp
%A Jing Wu
%A Lauren N Frady
%A Mark R Gilbert
%A Matthew G Ewend
%A Ryan E Bash
%A Stephanie M Cohen
%A Stephen V Frye
%A William C Zamboni
%A Xiaodong Wang
%A Yu-Ting Su
%J Archive of "Neuro-Oncology".
%D 2018
%R 10.1093/neuonc/nox111
%X Glioma-associated macrophages and microglia (GAMs) are components of the glioblastoma (GBM) microenvironment that express MerTK, a receptor tyrosine kinase that triggers efferocytosis and can suppress innate immune responses. The aim of the study was to define MerTK as a therapeutic target using an orally bioavailable inhibitor, UNC2025
%K glioblastoma
%K macrophage
%K MerTK
%K microenvironment
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761530/