%0 Journal Article
%T Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls
%A Annemieke J.M. Rozemuller
%A Eliane Kaaij
%A Frederik Barkhof
%A Jeroen J.G. Geurts
%A Laura E. Jonkman
%A Louise van der Weerd
%A Marjolein Bulk
%A Petra J.W. Pouwels
%A Wilma D.J. van de Berg
%A Yvon Galis-de Graaf
%J Archive of "NeuroImage : Clinical".
%D 2019
%R 10.1016/j.nicl.2019.101698
%X Well-characterized, high-quality brain tissue of non-neurological control subjects is a prerequisite to study the healthy aging brain, and can serve as a control for the study of neurological disorders. The Normal Aging Brain Collection Amsterdam (NABCA) provides a comprehensive collection of post-mortem (ultra-)high-field MRI (3Tesla and 7£¿Tesla) and neuropathological datasets of non-neurological controls. By providing MRI within the pipeline, NABCA uniquely stimulates translational neurosciences; from molecular and morphometric tissue studies to the clinical setting. We describe our pipeline, including a description of our on-call autopsy team, donor selection, in situ and ex vivo post-mortem MRI protocols, brain dissection and neuropathological diagnosis. A demographic, radiological and pathological overview of five selected cases on all these aspects is provided. Additionally, information is given on data management, data and tissue application procedures, including review by a scientific advisory board, and setting up a material transfer agreement before distribution of tissue. Finally, we focus on future prospects, which includes laying the foundation for a unique platform for neuroanatomical, histopathological and neuro-radiological education, of professionals, students and the general (lay) audience
%K Brain banking
%K Non-neurological controls
%K MRI
%K Neuropathology
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360607/