%0 Journal Article
%T Up-Regulation of Akt and Nav1.8 in BmK I-Induced Pain
%A Feng Jiang
%A Guokun Zhou
%A Jie Tao
%A Shichao Qin
%A Yong-Hua Ji
%A You Zhou
%A Yunlu Jiao
%A Zhi-Yong Tan
%J Archive of "Neuroscience Bulletin".
%D 2018
%R 10.1007/s12264-018-0222-x
%X Expression patterns of Akt,p-Akt, and Nav1.8 in DRGs after BmK I injection. A Representative Western blots of Akt, p-Akt, and Nav1.8 immunoreactivity at different time points following intraplantar injection of BmK I. B¨CG Quantification of band intensity for the ipsilateral (B, D, F) and contralateral (C, E, G) sides. The fold change for the density of the Akt, p-Akt, and Nav1.8 bands was calculated after normalization to control. H, I. Changes in the mRNA expression levels of Nav1.8. J Co-localization of Nav1.8 and Akt with CGRP neurons. K, L Ipsilateral (K) and contralateral (L) quantification of the co-localization in Nav1.8-positive cells. M, N Ipsilateral (M) and contralateral (N) quantification of the co-localization in pAkt-positive cells. *P£¿<£¿0.05, **P£¿<£¿0.01, and ***P£¿<£¿0.001 (n£¿=£¿3) compared with control groups. All data are presented as mean£¿¡À£¿SEM
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960458/