%0 Journal Article
%T Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma
%A Abdul-Kareem Ahmed
%A Agnieszka Bronisz
%A Brian W Guzik
%A Carmela Passaro
%A David A Reardon
%A E Antonio Chiocca
%A Estuardo Aguilar-Cordova
%A Franz Ricklefs
%A Gordon J Freeman
%A Hiroshi Nakashima
%A Johanna K Kaufmann
%A Kazue Kasai
%A Laura K Aguilar
%A Maria-Carmela Speranza
%A Michal O Nowicki
%A Patrick Y Wen
%A Prisca Obi
%A Ralph Weissleder
%A Sarah R Klein
%A Sean E Lawler
%A Xandra Breakefield
%J Archive of "Neuro-Oncology".
%D 2018
%R 10.1093/neuonc/nox139
%X Combined immunotherapy approaches are promising cancer treatments. We evaluated anti¨Cprogrammed cell death protein 1 (PD-1) treatment combined with gene-mediated cytotoxic immunotherapy (GMCI) performed by intratumoral injection of a prodrug metabolizing nonreplicating adenovirus (AdV-tk), providing in situ chemotherapy and immune stimulation
%K AdV-tk
%K anti-PD1
%K glioblastoma
%K immunotherapy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777502/