%0 Journal Article %T Optimization and Evaluation of Pretreatment Method for sp-ICP-MS to Reveal the Distribution of Silver Nanoparticles in the Body %A Hirofumi Tsujino %A Hong Tao %A Ikkei Tasaki %A Jian-Qing Gao %A Kazuma Higashisaka %A Kazumasa Hirata %A Kazuo Harada %A Kazuya Nagano %A Shigeru Saito %A Takuya Ishizaka %A Yasuo Tsutsumi %J Archive of "Nanoscale Research Letters". %D 2019 %R 10.1186/s11671-019-3016-9 %X Determination of optimal particle number per dwell time for accurate sp-ICP-MS analysis. A series of nAg solutions (600£¿fg/mL to 2,500£¿pg/mL) were analyzed by sp-ICP-MS. a To determine the relationship between the concentration of nAg100 and the number of detected particles, a curve for the detected particles (solid line) the theoretical values (dotted line) were plotted. b The number of detected particles subtracted from the theoretical value was plotted in the vertical axis to determine the optimal particle number. Each point is the result of a single trial (n =£¿1 %K Single particle inductively coupled plasma-mass spectrometry %K Engineered nanoparticles %K Silver nanoparticles %K Pretreatment of animal tissues %K Risk evaluation %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538717/