%0 Journal Article
%T A£¿randomised, investigator-initiated, clinical trial of the effects of fentanyl on P2Y12-receptor inhibition in patients with ST-elevation myocardial infarction who are pre-treated with crushed ticagrelor: rationale and design of the Opioids aNd crushed Ticagrelor In Myocardial infarction Evaluation (ON-TIME£¿3) trial
%A A. H. Tavenier
%A A. W. J. van ¡¯t Hof
%A E. Kedhi
%A J. P. Ottervanger
%A R. J. Slingerland
%A R. S. Hermanides
%A R. Tolsma
%A S. Rasoul
%A S. van Workum
%J Archive of "Netherlands Heart Journal".
%D 2019
%R 10.1007/s12471-019-1241-6
%X Fast and accurate platelet inhibition is an important therapeutic goal in the acute treatment of patients with ST-elevation myocardial infarction (STEMI). Platelet inhibitory effects induced by oral P2Y12-receptor antagonists are delayed in STEMI patients undergoing primary percutaneous coronary intervention (PCI) due to haemodynamic changes and delayed gastro-intestinal absorption. Concomitant use of opioids, although recommended in the American College of Cardiology/American Heart Association and European Society of Cardiology STEMI guidelines, further delays gastro-intestinal absorption. To date, trials investigating alternative analgesics in STEMI patients have been scarce. This trial aims to assess the feasibility of a novel drug strategy for treatment of STEMI patients with crushed ticagrelor in combination with paracetamol (acetaminophen) instead of opioids
%K ST-elevation myocardial infarction
%K Ticagrelor
%K Platelet inhibition
%K Primary percutaneous coronary intervention
%K Fentanyl
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439041/