%0 Journal Article
%T Translational applications of microRNAs in cancer, and therapeutic implications
%A Bruce G. Robinson
%A Grace T. Kwok
%A Himanshu Brahmbhatt
%A Jennifer A. MacDiarmid
%A Jing Ting Zhao
%A Jocelyn Weiss
%A Nancy Mugridge
%A Stan B. Sidhu
%J Archive of "Non-coding RNA Research".
%D 2017
%R 10.1016/j.ncrna.2017.12.002
%X The search for targeted novel therapies for cancer is ongoing. MicroRNAs (miRNAs) display a number of characteristics making them an attractive and realisable option. In this review, we explore these applications, ranging from diagnostics, prognostics, disease surveillance, to being a primary therapy or a tool to sensitise patients to treatment modalities such as chemotherapy and radiotherapy. We take a particular perspective towards miRNAs and their impact on rare cancers. Advancement in the delivery of miRNAs, from viral vectors and liposomal delivery to nanoparticle based, has led to a number of pre-clinical and clinical applications for microRNA cancer therapeutics. This is promising, especially in the setting of rare cancers
%K MicroRNAs
%K Cancer
%K Translational medicine
%K Rare cancers
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084838/