%0 Journal Article
%T What is the true clinical relevance of Simkania negevensis and other emerging Chlamydiales members?
%A C. Kebbi-Beghdadi
%A D. Baud
%A G. Greub
%A J. Li¨¦nard
%A L. Baskin
%A M. Vouga
%J Archive of "New Microbes and New Infections".
%D 2018
%R 10.1016/j.nmni.2018.01.001
%X Waddlia chondrophila and Simkania negevensis are emerging Chlamydia-related bacteria. Similar to the pathogenic organisms Chlamydia pneumoniae and Chlamydia trachomatis, these emerging bacteria are implicated in human genital infections and respiratory diseases. We used a screening strategy based on a newly developed S. negevensis¨Cspecific quantitative real-time PCR (qPCR) and a pan-Chlamydiales qPCR. We could not detect S. negevensis in 458 respiratory, genitourinary, cardiac and hepatic samples tested. One urethral swab was positive for W. chondrophila. We observed a low prevalence of Chlamydiales in respiratory samples (1/200, 0.5%), which suggests that C. pneumoniae is an uncommon respiratory pathogen. Furthermore, we screened 414 human serum samples from Switzerland, England and Israel and observed a low prevalence (<1%) of exposure to S. negevensis. Conversely, humans were commonly exposed to W. chondrophila, with seroprevalences ranging from 8.6% to 32.5%. S. negevensis is not a clinically relevant pathogen, but further research investigating the role of W. chondrophila is needed
%K Chlamydiae
%K intracellular bacteria
%K pathogen
%K pneumonia
%K emerging
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913364/