%0 Journal Article
%T Pan-cancer analysis connects tumor matrisome to immune response
%A Chwee Teck Lim
%A Joe Poh Sheng Yeong
%A Melvin Lee Kiang Chua
%A Su Bin Lim
%A Swee Jin Tan
%A Wan-Teck Lim
%J Archive of "NPJ Precision Oncology".
%D 2019
%R 10.1038/s41698-019-0087-0
%X Common matrisome variation in human cancers. a Schematic of the study design: 11 cancer type-specific, merged microarray-acquired dataset (MMD) were newly generated for parallel analyses with TCGA cohorts. b Circular plot illustrating the ranked position of matrisome genes based on differential expression (cancer vs. normal) in TCGA cohorts. 1 denotes the most differentially expressed gene (DEG). Black and gray lines represent the ranked position of generic and lung-specific TMI signature, respectively. c TMI in tumor vs. non-tumor tissues across 11 cancer types. The black horizontal line indicates the mean of the samples. ***Mann¨CWhitney U-test P£¿<£¿0.001, **P£¿<£¿0.01, *P£¿<£¿0.05. d Area under the ROC curves (AUCs) of the TMI classifier for all cancer types. Smooth ROC curves are drawn for MMDs (left) and TCGA cohorts (right
%K Cancer genomics
%K Predictive markers
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531473/