%0 Journal Article
%T Neonatal Maternal Deprivation Followed by Adult Stress Enhances Adrenergic Signaling to Advance Visceral Hypersensitivity
%A Guang-Yin Xu
%A Ping-An Zhang
%A Shan-Ping Yu
%A Shufen Hu
%A Wan-Jie Du
%A Xin Li
%A Xinghong Jiang
%J Archive of "Neuroscience Bulletin".
%D 2019
%R 10.1007/s12264-018-0318-3
%X Cartoon showing the experimental protocol for inducing visceral hypersensitivity. This protocol had two parts: neonatal maternal deprivation (NMD) and adult stress. NMD was imposed from postnatal day (PND) 2 to 15. The adult stress was of two kinds: adult single stressor (ASS): cold-restraint stress (CRS) for 45 min, and adult multiple stressors (AMSs): CRS for 45 min, forced-swimming stress (FSS) for 20 min, and water-avoidance stress (WAS) for 60 min. Behavioral testing was performed 6 h and 24 h after the termination of the last stressor. Molecular detection and norepinephrine (NE) measurements were performed 6 h after the termination of the last stressor. Whole-cell patch-clamp recordings were made 24 h after termination of the last stressor
%K Irritable bowel syndrome
%K Dorsal root ganglion
%K Norepinephrine
%K Visceral pain
%K Stress
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357269/