%0 Journal Article
%T Increased brain age in adults with Prader-Willi syndrome
%A Adriana M. Azor
%A Angelique Sadlon
%A Anthony J. Holland
%A Anthony P. Goldstone
%A James H. Cole
%A Katherine E. Manning
%A Maneesh C. Patel
%A Maureen Dumba
%J Archive of "NeuroImage : Clinical".
%D 2019
%R 10.1016/j.nicl.2019.101664
%X Prader-Willi syndrome (PWS) is the most common genetic obesity syndrome, with associated learning difficulties, neuroendocrine deficits, and behavioural and psychiatric problems. As the life expectancy of individuals with PWS increases, there is concern that alterations in brain structure associated with the syndrome, as a direct result of absent expression of PWS genes, and its metabolic complications and hormonal deficits, might cause early onset of physiological and brain aging
%K Body mass index
%K MRI
%K Structural neuroimaging
%K SNORD116
%K PWS
%K Obesity BMI
%K body mass index
%K GM
%K grey matter
%K PAD
%K predicted-age difference
%K PWS
%K Prader-Willi syndrome
%K WM
%K white matter
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412082/