%0 Journal Article
%T TNF-¦Á/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms
%A Bing Wang
%A Li-Hua Chen
%A Ran Guo
%A Ru-Rong Ji
%A Teng-Teng Liu
%A Tong Liu
%A Xiuhua Miao
%A Xue-Long Wang
%A Ya Huang
%A Yan Zhou
%J Archive of "Neuroscience Bulletin".
%D 2018
%R 10.1007/s12264-017-0124-3
%X TNFR1, but not TNFR2, is required for both histaminergic and non-histaminergic itch in mice. A Time course of acute histaminergic itch induced by compound 48/80 (48/80) in wild-type (WT), TNFR1-KO, TNFR2-KO, and TNFR1/R2 DKO mice. B Total scratching bouts within 30 min induced by 48/80 in all four groups of mice. C Time course of acute non-histaminergic itch induced by chloroquine (CQ) in WT, TNFR1-KO, TNFR2-KO, and TNFR1/R2 DKO mice. D Total scratching bouts within 30 min induced by CQ in all four groups of mice. Data are presented as mean ¡À SEM ( P < 0.05 vs WT group one-way ANOVA followed by Bonferroni post hoc test; n = 5¨C7 mice per group)
%K Itch
%K Tumor necrosis factor
%K Tumor necrosis factor receptor
%K Spinal cord
%K Central sensitization
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799114/