%0 Journal Article %T Extensively Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem Guiana Extended Spectrum ¦Â-Lactamase Enzymes: A Newly Emerging Threat in the United States %A An Q Dinh %A Audrey Wanger %A Ayesha Khan %A Blake Hanson %A Cesar A Arias %A Lorena Diaz %A Luis Ostrosky-Zeichner %A Rafael Rios %A Timothy Palzkill %A Truc T Tran %A William C Shropshire %A William R Miller %A Zhizeng Sun %J Archive of "Open Forum Infectious Diseases". %D 2019 %R 10.1093/ofid/ofz273 %X Treatment of serious infections due to multidrug-resistant (MDR) Pseudomonas aeruginosa remains a challenge, despite the introduction of novel therapeutics. In this study, we report 2 extensively drug-resistant clinical isolates of sequence type (ST) 309 P aeruginosa resistant to all ¦Â-lactams, including the novel combinations ceftolozane/tazobactam, ceftazidime/avibactam, and meropenem/vaborbactam %K carbapenem-resistant Pseudomonas aeruginosa %K ceftolozane/tazobactam %K combination therapy %K GES beta-lactamase %U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602888/