%0 Journal Article
%T Long-Acting Lipoglycopeptides: ˇ°Lineless Antibioticsˇ± for Serious Infections in Persons Who Use Drugs
%A Brian T Montague
%A Gerard R Barber
%A Martin Krsak
%A Matthew A Miller
%A R Brett McQueen
%A Taylor Morrisette
%J Archive of "Open Forum Infectious Diseases".
%D 2019
%R 10.1093/ofid/ofz274
%X Injection drug use is associated with serious infections. Due to challenges with medical management of addiction, relapses and additional infections are common. Persons who use drugs (PWUD) are more likely to leave against medical advice before completing treatment, which could result in treatment failure. Prolonged intravenous (IV) antimicrobial therapy in PWUD may be complicated by concern for IV catheter misuse, sometimes requiring prolonged hospitalization. Ideal alternatives would provide the following: (1) high success rate; (2) reduced rate of medical complications; (3) improved safety profiles; and (4) improved cost-effectiveness. Long-acting lipoglycopeptides present such opportunity for treatment of serious Gram-positive infections
%K dalbavancin
%K injection drug use
%K intravenous drug use
%K oritavancin
%K Staphylococcus
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602887/