%0 Journal Article
%T E4orf1 protein reduces the need for endogenous insulin
%A Md Akheruzzaman
%A Nikhil V. Dhurandhar
%A Swetha Peddibhotla
%A Vijay Hegde
%J Archive of "Nutrition & Diabetes".
%D 2019
%R 10.1038/s41387-019-0085-x
%X Mean£¿¡À£¿SD. a GTT was performed in E4orf1 transgenic and non-transgenic mice (after 4£¿h of starvation) by injecting D-glucose (1.5£¿mg/kg of body weight) intra-peritoneally. Blood glucose was determined at 0, 15, 30, 60, and 120£¿min post-glucose load shows significantly faster glucose clearance in E4orf1-expressing mice. b Body weight did not differ significantly between the two groups. The hyperinsulinemic¨Ceuglycemic clamp studies performed on these mice do not show any difference in c fasting blood glucose (mg/dL), d glucose infusion rate, or e plasma insulin (ng/mL). The groups were compared using t-test, *p£¿¡Ü£¿0.0
%K Endocrinology
%K Type 2 diabetes
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6534626/