%0 Journal Article
%T Poldip2 takes a central role in metabolic reprograming
%A Alejandra San Martin
%A Felipe Paredes
%A Izabela Suster
%J Archive of "Oncoscience".
%D 2018
%R 10.18632/oncoscience.419
%X In 1951 Lester Reed isolated the first crystals of an ˇ°acetate-replacing factorˇ±, appropriately named for its ability to replace acetate during the growth of lactic acid bacteria [1]; it was renamed ¦Á-lipoic acid (ALA) by Esmond Snell. After decades of research, we now recognize that ALA is a cyclic disulfide containing fatty acid that undergoes reversible redox ring opening/closing, which is coupled with the oxidative decarboxylation of ¦Á-keto acids. Thus, this essential prosthetic group occupies a critical position in energy metabolism by regulating the activity of the tricarboxylic acid (TCA) cycle
%K lipoylation
%K poldip2
%K TCA
%K hypoxia
%K cancer
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049324/