%0 Journal Article
%T Targeting PIM kinases to oppose hypoxia-mediated therapeutic resistance
%A Noel A. Warfel
%A Shailender S. Chauhan
%J Archive of "Oncoscience".
%D 2018
%R 10.18632/oncoscience.458
%X PIM kinase family members have been implicated as important factors in the progression and prognosis of various malignancies, including leukemia, breast, and prostate cancer. As a result, PIM kinases are emerging as potential targe ts for solid tumors. In fact, many pharmacological inhibitors of PIM kinases are already under clinical trials [1]. A growing body of evidence suggests that PIM kinases are particularly important in the context of cellular stress, such as hypoxia. Notably, PIM kinase expression is increased in hypoxia in a HIF-1- independent manner, which makes PIM inhibition a novel approach to target the hypoxic tumor microenvironment. Recent reports highlight hypoxia-induced PIM kinase expression as a novel signal transduction pathway that provides protection against hypoxic stress by promoting survival and angiogenesis (Figure (Figure1)1) [2,3]
%K PIM kinase
%K hypoxia
%K angiogenesis
%K Nrf2
%K therapeutic resistance
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231444/