%0 Journal Article
%T Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold
%A Concettina La Motta
%A Giulia Nesi
%A Maria Digiacomo
%A Simona Rapposelli
%A Simona Sestito
%A Stefania Sartini
%A Vito Coviello
%J Archive of "The Open Medicinal Chemistry Journal".
%D 2017
%R 10.2174/1874104501711010009
%X Aldose reductase, the first enzyme of the polyol pathway, is the key determinant for the pathogenesis of long term diabetic complications. Accordingly, its inhibition represents the major therapeutic strategy to treat this kind of pathologies
%K Aldose reductase enzyme
%K Diabetic complications
%K Spiromorpholinone derivatives
%K Aldose reductase inhibitors (ARI)
%K Spiro-oxazolidinones
%K Spirobenzopyran derivatives
%K ARL2
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418920/