%0 Journal Article
%T Development of an Ad5H3 Chimera Using the ˇ°Antigen Capsid-Incorporationˇ± Strategy for an Alternative Vaccination Approach
%A Alexandre Krendelchtchikov
%A Alison E. Johnston
%A Linlin Gu
%A Mert Icyuz
%A Qiana L. Matthews
%A Valentina Krendelchtchikova
%J Archive of "The Open Virology Journal".
%D 2016
%R 10.2174/1874357901610010010
%X Adenovirus type 5 (Ad5) achieved success as a conventional transgene vaccine vector in preclinical trials, however; achieved poor efficiency in some of the clinical trials, due to the major hurdle associated with Ad5 pre-existing immunity (PEI) in the majority of the human population
%K Adenovirus type 3 (Ad3)
%K Adenovirus type 5 (Ad5)
%K Ad5 pre-existing immunity (PEI)
%K Antigen Capsid-Incorporation strategy
%K Chimeric Ad5H3
%K Humoral immunity
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892130/