%0 Journal Article
%T Original research article: Heritability in genetic heart disease: the role of genetic background
%A Alexa Vermeer
%A Annika Rydberg
%A Arthur J Moss
%A Arthur Wilde
%A Heikki Swan
%A Iacopo Olivotto
%A Imke Christiaans
%A J Martijn Bos
%A J Peter van Tintelen
%A Jacob Tfelt-Hansen
%A Jasper van der Smagt
%A Joeri A Jansweijer
%A Juan R Gimeno
%A Karin Y van Spaendonck-Zwarts
%A Maarten van den Berg
%A Michael Ackerman
%A Michael W T Tanck
%A Philippe Charron
%A Sylvia Priori
%A Yigal M Pinto
%J Archive of "Open Heart".
%D 2019
%R 10.1136/openhrt-2018-000929
%X Mutations in genes encoding ion channels or sarcomeric proteins are an important cause of hereditary cardiac disease. However, the severity of the resultant disease varies considerably even among those with an identical mutation. Such clinical variation is often thought to be explained largely by differences in genetic background or ¡®modifier genes¡¯. We aimed to test the prediction that identical genetic backgrounds result in largely similar clinical expression of a cardiac disease causing mutation, by studying the clinical expression of mutations causing cardiac disease in monozygotic twins
%K Genetics
%K Twin Study
%K Cardiomyopathy
%K Channelopathy
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546190/