%0 Journal Article
%T Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties
%A Aikaterini Peperidou
%A Angelo Carotti
%A Dimitra J. Hadjipavlou-Litina
%A Konstantinos E. Litinas
%A Marco Catto
%A Michael G. Kallitsakis
%J Archive of "The Open Medicinal Chemistry Journal".
%D 2017
%R 10.2174/1874104501711010196
%X The 1,3-dipolar cycloaddition reactions of nitrile oxides formed in situ (in the presence of NCS and Et3N) from the oximes of (purin-9-yl)acetaldehyde or (coumarinyloxy)acetaldehyde with allyloxycoumarins or 9-allylpurines, respectively resulted in 3,5-disubstituted isoxazolines. The similar reactions of propargyloxycoumarins or 9-propargylpurines led to 3,5-disubstituted isoxazoles by treatment with PIDA and catalytic amount of TFA
%K Modified Homo-N-nucleosides
%K Purines
%K Coumarins
%K 1
%K 3-dipolar Cycloaddition Reaction
%K Antioxidant activity
%K Anti-lipid peroxidation activity
%K Alzheimer¡¯s Disease
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748833/