%0 Journal Article
%T System immunology-based identification of blood transcriptional modules correlating to antibody responses in sheep
%A Artur Summerfield
%A Beatrice Zumkehr
%A Christophe Barnier-Quer
%A Ga£¿l Auray
%A Kurt Wyler
%A Livia Brunner
%A Michael Hubert Stoffel
%A Nicolas Collin
%A Obdulio Garc¨ªa-Nicol¨¢s
%A Roman Othmar Braun
%A R¨¦my Bruggmann
%A Sylvie Python
%A V¨¦ronique Gaschen
%J Archive of "NPJ Vaccines".
%D 2018
%R 10.1038/s41541-018-0078-0
%X Neutralizing antibodies, haptoglobin and differentially expressed genes in PBMC induced by vaccination. a Study design. b Serum neutralizing antibody titers following vaccination of sheep with antigen in phosphate buffered saline (PBS), antigen formulated in liposomes (L) and antigen formulated in liposomes with TLRL (L(TLRL)). c Vaccine-induced haptoglobin responses. d Vulcano plots showing differentially expressed genes which were up- or downregulation on day 3 (D3) and day 7 (D7) compared with before immunization, respectively. Green dots represent significant genes (p adjusted£¿<£¿0.05). Digits in the plots indicate the number of significantly down or upregulated genes. In b and c, statistical significant differences between two groups were calculated using unpaired two-way ANOVA with repeated measures followed by Tukey¡¯s multiple comparisons test (***p£¿<£¿0.001; **p£¿<£¿0.002; *p£¿<£¿0.033
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170373/