%0 Journal Article
%T Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia¨CReperfusion Injury
%A Christopher Bell
%A Emek Blair
%A Gregory R. Giordano
%A Hunter L. Paris
%A Janelle L. Davis
%A Joseph W. Beals
%A Melani M. Schweder
%A Rebecca L. Scalzo
%A Scott E. Binns
%J Archive of "Nutrition and Metabolic Insights".
%D 2016
%R 10.4137/NMI.S39764
%X Intravenous administration of vitamin C has been shown to decrease oxidative stress and, in some instances, improve physiological function in adult humans. Oral vitamin C administration is typically less effective than intravenous, due in part to inferior vitamin C bioavailability. The purpose of this study was to determine the efficacy of oral delivery of vitamin C encapsulated in liposomes. On 4 separate randomly ordered occasions, 11 men and women were administered an oral placebo, or 4 g of vitamin C via oral, oral liposomal, or intravenous delivery. The data indicate that oral delivery of 4 g of vitamin C encapsulated in liposomes (1) produces circulating concentrations of vitamin C that are greater than unencapsulated oral but less than intravenous administration and (2) provides protection from ischemia¨Creperfusion-mediated oxidative stress that is similar to the protection provided by unencapsulated oral and intravenous administrations
%K liposome
%K oral
%K intravenous
%K oxidative stress
%K thiobarbituric acid reactive substances
%U https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915787/